Publications by authors named "D R Cyr"
Background: Coronavirus disease 2019 (COVID-19) pneumonia requires considerable healthcare resources.
Research Objective: Examine if a single dose of infliximab or abatacept, in addition to remdesivir and steroids, decreased resource utilization among participants hospitalized with COVID-19 pneumonia.
Study Design And Methods: Accelerating COVID-19 Therapeutic Interventions and Vaccines Immunomodulator (ACTIV-1 IM) master protocol was a randomized, placebo-controlled trial examining the potential benefit in time to recovery and mortality of immunomodulators infliximab, abatacept, and cenicriviroc.
Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder, in which deficiency of glutaryl-CoA dehydrogenase leads to accumulation of glutaric acid (GA) and 3-hydroxyglutaric acid (3-HG). Some low excretors may exhibit only slight elevation of urinary 3-HG, with normal urinary GA, yet are at significant risk of severe clinical disease. Accurate quantitation of urinary 3-HG is crucial in diagnostic workup for GA1, but in this context, current gas chromatography-mass spectrometry (GC-MS) methods have inherent analytical challenges.
View Article and Find Full Text PDFBackground: The win ratio (WR) is an emerging alternative for reporting composite outcomes, prioritizing clinically significant events such as mortality while incorporating surrogate measures. However, its benefits should be weighed against limitations, particularly the influence of lower hierarchical outcomes. This secondary analysis of the PARAGLIDE-HF trial performed a WR sensitivity analysis using a modified hierarchical composite outcome to assess the utility of WR sensitivity analysis and the efficacy of sacubitril/valsartan versus valsartan.
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- The study examines changes in gap junction protein expression in the rat epididymis during postnatal development, revealing decreased levels of Gjb2 (Cx26) and increased levels of other connexins (Cx32, Cx30.3, and Cx31.1).
- The research aims to identify mechanisms behind these expression changes, indicating that decreased Gjb2 does not trigger compensatory mechanisms in principal cells and noting hormone interactions.
- Findings show that androgens, particularly testosterone, and glucocorticoids like dexamethasone significantly influence the expression of these connexins, with orchidectomy revealing hormonal influence on GJB2 and GJB1 levels in the epididymis.
Article Synopsis
- The study investigates abdominal venous leiomyosarcoma (AV-LMS), focusing on its origins from veins associated with the sex-hormone drainage pathway (SHDP).
- A retrospective analysis of imaging from 155 patients with confirmed non-uterine abdominal/pelvic LMS revealed that more than half of the tumors originated from venous structures, particularly those linked to the SHDP, including adrenal and ovarian veins.
- Key findings indicate that tumors from the SHDP are prevalent and may lead to a lower risk of distant metastases at diagnosis, with tumor size and SHDP origin being critical factors in predicting metastasis risk.