Publications by authors named "D R Curran"
Article Synopsis
- The LUX-ZEPLIN (LZ) experiment is a significant scientific study using a dual-phase xenon chamber located underground in South Dakota to search for dark matter interactions.
- The study extends existing theories to include relativistic effects, providing new constraints on the interactions between weakly interacting massive particles and nucleons based on their electric and magnetic dipole moments.
- Results include 90% confidence level limits on the coupling strength of five different interactions, analyzed over a specific energy range, which advances our understanding in particle physics beyond previous nonrelativistic effective field theories.
Article Synopsis
- Respiratory syncytial virus (RSV) commonly causes respiratory illnesses, especially severe in adults over 60 or those with chronic conditions; a study examined the cost-effectiveness of the RSVPreF3 vaccine for this age group in the US.* -
- A multi-cohort Markov model compared outcomes of not vaccinating versus a one-time vaccination, estimating that vaccinating approximately 52.7 million older adults would save nearly 244,424 quality-adjusted life years (QALYs) at a societal cost of about $4.5 billion over five years.* -
- The analysis indicated that the adjuvanted RSVPreF3 vaccine is cost-effective, with an incremental cost-effectiveness ratio (
Introduction: In 2023, recombinant zoster vaccine (RZV) replaced zoster vaccine live (ZVL) vaccine in the UK National Immunisation Programme (NIP) for prevention of herpes zoster (HZ). The vaccination age was reduced from 70 to 65 years, with a subsequent planned reduction to 60 years. This modelling study aimed to evaluate the public health impact (PHI) of RZV vaccination in the 70 years of age (YOA) population and in younger individuals 65 and 60 YOA.
View Article and Find Full Text PDFis the causative agent of gonorrhea, an on-going public health problem due in part to the lack of success with efforts to develop an efficacious vaccine to prevent this sexually transmitted infection. An attractive candidate vaccine antigen because of its essential function and surface exposure, the gonococcal transferrin binding protein B (TbpB) exhibits high levels of antigenic variability which poses a significant obstacle in evoking a broadly protective vaccine composition. Here, we utilize phylogenetic information to rationally select TbpB variants for inclusion into a potential gonococcal vaccine and identify two TbpB variants that when formulated together elicit a highly cross-reactive antibody response in both rabbits and mice against a diverse panel of TbpB variants and clinically relevant gonococcal strains.
View Article and Find Full Text PDFIntroduction: The objective of this work was to summarize the incidence of herpes zoster (HZ) complications in different populations.
Methods: Systematic literature review of PubMed, Embase, and Virtual Health Library records between January 1, 2002 and October 20, 2022 using search strings for HZ, complications, and frequency measurements.
Results: The review included 124 studies, most conducted in the general population (n = 93) and on individuals with comorbidities (n = 41) ≥ 18 years of age.