Publications by authors named "D R Cortes"
We report here a new ligand for the peroxisome-proliferator-activated receptor type α (PPARα), an N-tosyl hydrazone benzopyran that was designed throughout the mapping of the polar zone of the binding site of PPARα; such a compound displays a strong activity on this receptor that is comparable to that of the reference compound WY-14643. For the design of the -tosyl hydrazone benzopyran, we have carried out an exhaustive conformational study of WY-14643 and a previously reported hydrazine benzopyran derivative using conformational potential energy surfaces (PES). This study allowed us to map in a systematic way the entire binding site of the PPARα.
View Article and Find Full Text PDFThe Development of a Brief but Comprehensive Therapeutic Assessment Protocol for the Screening and Support of Youth in the Community to Address the Youth Mental Health Crisis.
Brain Sci
November 2024
Article Synopsis
- The study aimed to assess the acceptability and feasibility of the Screening and Support for Youth (SASY), a community-based program that provides mental health screening and support for diverse youth.
- Using various tools, the SASY screening evaluated symptoms, functioning, and clinical risks, leading to personalized insights for participants during motivational interviews and options for online interventions.
- Innovative recruitment methods, enhanced by the pandemic (like using QR codes), successfully increased participation, particularly among Black or African American and Hispanic youth, showing that combining online and offline strategies can effectively engage a diverse population.
Background: Advances in neonatal care have increased survival rates for premature or low birth weight (LBW) infants but raised concerns about long-term neurosensory and psychomotor challenges. : to investigate perinatal factors linked to visual and auditory problems in ex-preterm or LBW young adults, assessing their long-term quality of life.
Methods: Participants from a 20-year-old randomised controlled trial comparing Kangaroo-Mother Care (KMC) to conventional care were re-enrolled.