The History of Vertical Flight and Air Medical Transport.

Vertical flight was sought-after by scientists for centuries, finding early beginnings in children's toys and slowly developing into the modern helicopter. For centuries, true success was elusive, and many machines failed to achieve safe, controlled flight. Despite slow progress, vertical flight enthusiasts were unrelenting and continued trialing new concepts until one finally rose above the rest.

Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.

Biomimetic materials with biomechanical properties resembling those of native tissues while providing an environment for cell growth and tissue formation, are vital for tissue engineering (TE). Mechanical anisotropy is an important property of native cardiovascular tissues and directly influences tissue function. This study reports fabrication of anisotropic cell-seeded constructs while retaining control over the construct's architecture and distribution of cells.

Insulin translocates PKC-epsilon and phorbol esters induce and persistently translocate PKC-beta 2 in BC3H-1 myocytes.

Initial studies suggested that insulin increases diacylglycerol and activates protein kinase C (PKC) in BC3H-1 myocytes. In these earlier studies, insulin was found to translocate PKC-beta, but the presence of PKC-epsilon was not appreciated. More recently, the presence of PKC-epsilon was documented, but PKC-beta was not detected, and it was questioned whether insulin activates PKC in BC3H-1 myocytes [Stumpo, D.