A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.

Mitochondria are the main site for generating reactive oxygen species, which are key players in diverse biological processes. However, the molecular pathways of redox signal transduction from the matrix to the cytosol are poorly defined. Here we report an inside-out redox signal of mitochondria.

Miro1 Impairment in a Parkinson's At-Risk Cohort.

There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced degradation in fibroblasts from a large number of PD patients and several at-risk individuals.

Reprint of: A healthy island blue space: From space of detention to site of sanctuary.

Island blue spaces are associated with restorative potential, but few studies examine this proposition when an island's use has changed over time. We examine Rotoroa Island (near Auckland, New Zealand) where, for almost a century, the Salvation Army ran an alcohol treatment facility. The island's relative isolation was central to its mixed therapeutic and carceral roles.

A healthy island blue space: from space of detention to site of sanctuary.

Island blue spaces are associated with restorative potential, but few studies examine this proposition when an island׳s use has changed over time. We examine Rotoroa Island (near Auckland, New Zealand) where, for almost a century, the Salvation Army ran an alcohol treatment facility. The island׳s relative isolation was central to its mixed therapeutic and carceral roles.