Publications by authors named "D R Cave"
A distinct feature of pancreatic ductal adenocarcinoma (PDAC) is a prominent tumor microenvironment (TME) with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. The dynamic crosstalk between cancer cells and the dense stromal compartment leads to spatially and temporally heterogeneous metabolic alterations, such as acidic pH that contributes to drug resistance in PDAC. Thus, monitoring the extracellular pH metabolic fluctuations within the TME is crucial to predict and to quantify anticancer drug efficacy.
View Article and Find Full Text PDFAim: To evaluate an 'On-Demand' snack service in a rehabilitation setting for satisfaction, intake, waste and cost.
Methods: In September 2021, a trial of an 'On-Demand' snack service was conducted on two general rehabilitation wards in a purpose-built rehabilitation hospital. A retrospective comparison of pre-implementation, 1-month and 8-month post-implementation audit data was used to evaluate staff and patient satisfaction, nutritional intake, waste and cost (labour and food).
The genus comprises free-living amoebae distributed in a wide variety of environments. These amoebae are clinically significant, causing opportunistic infections in humans and other animals. Despite this, limited data on sequence types and alleles are available in Italy.
View Article and Find Full Text PDFPancreatic cancer represents a formidable challenge in oncology, primarily due to its aggressive nature and limited therapeutic options. The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC), the main form of pancreatic cancer, remains disappointingly poor with a 5-year overall survival of only 5%. Almost 95% of PDAC patients harbor Kirsten rat sarcoma virus (KRAS) oncogenic mutations.
View Article and Find Full Text PDFArticle Synopsis
- * Recent research in Italy presents the first molecular characterization of E. bieneusi in symptomatic patients, involving 410 faecal samples that tested positive using a molecular detection method.
- * Three different genotypes (A, C, and K) of E. bieneusi were identified, raising questions about its zoonotic potential and emphasizing the need for further studies to understand its impact on human and animal health as well as the environment.