Publications by authors named "D R Byrd"
Objective: Accumulation of hydrophobic bile acids is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic bile acids. The impact of diet on secondary bile acid (BA) derivative production has not been determined.
View Article and Find Full Text PDFObjective: Research examining (MCI) criteria in diverse and/or health-disparate populations is limited. There is a critical need to investigate the predictive validity for incident dementia of widely used MCI definitions in diverse populations.
Method: Eligible participants were non-Hispanic White or Black Bronx community residents, free of dementia at enrollment, with at least one annual follow-up visit after baseline.
Purpose: To characterize dietary patterns and examine associations with cross-sectional and longitudinal changes in quality of life (QOL) over approximately one year after colorectal cancer (CRC) diagnosis.
Methods: The ColoCare Study is an international, multi-center, prospective cohort study of newly diagnosed CRC survivors of any stage. A subset of participants with CRC in the United States completed patient-reported outcome measures at 6- and 12-months post-enrollment, including the Food Frequency Questionnaire (FFQ) and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30).
Article Synopsis
- Cachexia, a condition linked to cancer and associated with a poor prognosis, accounts for about 20% of cancer-related deaths, yet the connection between Fusobacterium nucleatum (Fn) and cachexia in colorectal cancer (CRC) remains unclear.
- In a study involving 87 CRC patients, researchers found that high levels of Fn in pre-surgical stool samples significantly increased the risk of developing cachexia six months after surgery.
- These results are the first to connect Fn abundance with cachexia in CRC, highlighting potential biological mechanisms and treatment avenues; however, the study's small sample size calls for more research to confirm these findings.
Article Synopsis
- - Alzheimer's disease research registries are vital for finding participants, but enrollment is low among at-risk racial and ethnic groups.
- - This study uses the Reasoned Action Approach to develop persuasive recruitment messages that target underrepresented groups, with survey data collected from 1,501 adults aged 50-80.
- - Findings show that attitudes are key motivators for signing up, while social norms and perceived capacity vary among groups, suggesting that tailored messages highlighting societal benefits could boost participation.