Publications by authors named "D R Bakker"
In contrast to adult mammalian hearts, the adult zebrafish heart efficiently replaces cardiomyocytes lost after injury. Here we reveal shared and species-specific injury response pathways and a correlation between Hmga1, an architectural non-histone protein, and regenerative capacity, as Hmga1 is required and sufficient to induce cardiomyocyte proliferation and required for heart regeneration. In addition, Hmga1 was shown to reactivate developmentally silenced genes, likely through modulation of H3K27me3 levels, poising them for a pro-regenerative gene program.
View Article and Find Full Text PDFIntroduction And Objectives: Tralokinumab-a biological that specifically targets interleukin-13-is one of the newer advanced systemic treatments for patients with moderate-to-severe atopic dermatitis (AD). Although safety and efficacy have been shown in phase-III clinical trials, daily practice data are needed. Therefore, the aim of this study was to evaluate 28-week safety and effectiveness, serum proteins and total IgE levels in adult AD patients treated with tralokinumab in daily practice.
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- Biological catch bonds, unlike regular adhesives, become stronger under increased tension, playing a crucial role in cell adhesion and communication.
- The study introduces the "fish-hook," a specially designed DNA catch bond that allows for precise adjustments in how it responds to tension.
- By modeling and testing these DNA structures, the research highlights the potential for reprogramming biological interactions and creating innovative materials that can strengthen under force.
Article Synopsis
- Bovine tuberculosis (bTB) is a disease affecting cattle, especially common in crossbred cows in Ethiopia, but there aren't enough checks to find it.
- In a study, scientists checked over 7,640 cattle at slaughterhouses and found that only 2.3% had signs of bTB, with crossbred cows being at higher risk.
- Most of the sick cattle had problems in their lungs or lymph nodes, and tests confirmed that M. bovis, a type of bacteria, was responsible for the infections.