Anlotinib enhances the pro-apoptotic effect of APG-115 on acute myeloid leukemia cell lines by inhibiting the P13K/AKT signaling pathway.

Background: APG-115 is a novel small-molecule selective inhibitor that destabilizes the p53-MDM2 complex and activates p53-mediated apoptosis in tumor cells. Anlotinib inhibits tumor angiogenesis and promotes apoptosis. In this study, we investigated the apoptotic effect and potential mechanism of APG-115 and anlotinib combination on AML cell lines with different p53 backgrounds.

Effects of naturally aged microplastics on arsenic and cadmium accumulation in lettuce: Insights into rhizosphere microecology.

Naturally aged microplastics (NAMPs) are commonly found in farmland soils contaminated with heavy metals (HMs), such as arsenic (As) and cadmium (Cd); yet their combined effects on soil-plant ecosystems remain poorly understood. In this study, we investigated the toxic effects of NAMPs and As-Cd on lettuce, considering the influence of earthworm activity, and examined changes in As-Cd bioavailability in the rhizosphere. Four experimental systems were established: soil-only, soil-lettuce, soil-earthworms, and soil-lettuce-earthworms systems, with four NAMPs concentrations (0, 0.

Cultivated meat microbiological safety considerations and practices.

Cultivated meat, produced using cell culture technology, is an alternative to conventional meat production that avoids the risks from enteric pathogens associated with animal slaughter and processing. Cultivated meat therefore has significant theoretical microbiological safety advantages, though limited information is available to validate this. This review discusses sources and vectors of microbial contamination throughout cultivated meat production, introduces industry survey data to evaluate current industry practices for monitoring and mitigating these hazards, and highlights future research needs.

Warmth and Control: Examining the Associations between Chinese Parenting Behaviors and Children's Academic Performance in Different Parent-Child Dyads.

Few studies have comprehensively examined the reciprocal relation between specific parenting practices and children's academic performance across parent and child gender. The present study investigated the bidirectional associations between parental warmth/control and children's academic performance using a three-wave longitudinal multi-informant design. A total of 814 families (M = 10.

Plant Coumarin Metabolism-Microbe Interactions: An Effective Strategy for Reducing Imidacloprid Residues and Enhancing the Nutritional Quality of Pepper.

Imidacloprid (IMI) stress positively correlates with the potential of coumarins to alleviate abiotic stress. However, little is known about the pathways and mechanisms by which coumarin reduces the IMI residue by regulating plant secondary metabolism and plant-microbe interactions. This study examined the impact of coumarin on the uptake, translocation, and metabolism of IMI in pepper plants by modulating the signal molecule levels and microbial communities in the rhizosphere and phyllosphere.