Value of Label-Free Ubiquitin-Proteomic Analysis on Defining the Protective Mechanism of Valsartan against Doxorubicin-Induced Heart Failure.

Introduction: The cardiotoxicity and subsequent Heart Failure (HF) induced by Doxorubicin (DOX) limit the clinical application of DOX. Valsartan (Val) is an angiotensin II receptor blocker that could attenuate the HF induced by DOX. However, the underlying mechanism of Val in this process is not fully understood.

Construction of Luminescent Three-Dimensional Covalent Organic Frameworks for Molecular Decoding of Wide Organic Compounds.

Constructing highly conjugated three-dimensional covalent organic frameworks (3D COFs), particularly those with luminescent features, remains a significant challenge. In this work, we successfully synthesized a 3D COF, named 3D-Py-SP-COF, using a rigid and orthogonal spirobifluorene building block for the spatial 3D structure construction and planar pyrene as luminescent units. The incorporation of the pyrene and the unique rigid 3D network structure endow 3D-Py-SP-COF with fluorescent properties.

Miniaturized fiber optic accelerometer incorporating liquid metal as the proof mass.

The inertial element of a solid block is commonly used as the proof mass in traditional accelerometers. However, it is challenging to accommodate both the high-density solid-state proof mass and the highly elastic component simultaneously in a miniature sensor, which makes it difficult for the sensors to maintain comparable sensing performance at a miniaturized size. Here, a novel, to the best of our knowledge, liquid metal-based fiber optic accelerometer (LMFOA) is proposed for the first time to meet this requirement.

Structurally and Electronically Anisotropic Nature of Bridgman-Grown CsSbBr Perovskite Single Crystal toward Efficient Photodetector.

CsSbBr, as a sort of novel lead-free perovskite single crystal, has the merits of high carrier mobility and a long diffusion length. However, the large-sized and high-crystallized CsSbBr single crystals are not easily obtained. Herein, we apply the vertical Bridgman method to grow centimeter-sized CsSbBr single crystal.

Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families.

Objective: Spinal muscular atrophy (SMA) is a motor neuron disorder encompassing 5q and non-5q forms, causing muscle weakness and atrophy due to spinal cord cell degeneration. Understanding its genetic basis is crucial for genetic counseling and personalized treatment options.

Methods: This study retrospectively analyzed families of patients suspected of SMA at our institution from February 2006 to March 2024.