Publications by authors named "D Pytel"
Article Synopsis
- * The review focuses on anaerobic environments near the brain, which may foster changes in microbial communities that could contribute to neurodegenerative processes.
- * It highlights two main sources of bacteria that can reach the brain: oral dysbiosis in dental pockets and gut microbiota, and emphasizes the need for further research into these connections.
The term glaucoma encompasses various neurodegenerative eye disorders, among which the most common is primary open-angle glaucoma (POAG). Recently, the essential role of human retinal astrocytes (HRA) in glaucoma progression has been placed in the spotlight. It has been found that placing the endoplasmic reticulum (ER) under stress and activating PERK leads to apoptosis of HRA cells, which inhibits their neuroprotective effect in the course of glaucoma.
View Article and Find Full Text PDFBackground: The SARS-CoV-2 pandemic saw the rapid rise, global spread, and diversification of the omicron variant in 2022. Given the overwhelming dominance of this variant globally and its diverse lineages, there is an urgent need to ensure that diagnostic assays are capable of detecting widely circulating omicron sub-lineages.
Study Design: Remnant clinical VTM samples from SARS-CoV-2 PCR confirmed infections (n = 733) collected in Wisconsin (n = 94), New York (n = 267), and South Carolina (n = 372) throughout 2022 were sequenced, classified, and tested with m2000 RealTime SARS-CoV-2, Alinity m SARS-CoV-2, ID NOW COVID-19 v2.
<b> Introduction:</b> The newest data has reported that endoplasmic reticulum (ER) stress and PERK-dependent Unfolded Protein Response (UPR) signaling pathway may constitute a key factor in colorectal cancer (CRC) pathogenesis on the molecular level. Nowadays used anti-cancer treatment strategies are still insufficient, since patients suffer from various side effects that are directly evoked via therapeutic agents characterized by non-specific action in normal and cancer cells. </br></br> <b>Aim:</b> Thereby, the main aim of the presented research was to analyze the effectiveness of the small-molecule PERK inhibitor NCI 12487 in an in vitro cellular model of CRC.
View Article and Find Full Text PDFArticle Synopsis
- Heterogeneous Nuclear Ribonucleoprotein K (hnRNPK) is an RNA binding protein involved in various cellular processes and its abnormal presence in the cytoplasm of tumors is linked to poor outcomes.
- The SCF E3 ubiquitin ligase plays a crucial role by regulating hnRNPK through a process called K63 polyubiquitylation, which limits its ability to interact with target mRNAs crucial for cell behavior.
- The study identifies that loss of SCF leads to increased cell movement and tumor growth, particularly through the upregulation of c-Myc, indicating potential therapeutic targets for cancers with dysregulated hnRNPK and c-Myc.