Publications by authors named "D Psimaras"
Background And Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is perceived differently by patients and physicians, complicating its assessment. Current recommendations advocate combining clinical and patient-reported outcomes measures, but this approach can be challenging in patient care. This multicenter European study aims to bridge the gap between patients' perceptions and neurological impairments by aligning both perspectives to improve treatment decision-making.
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- The study investigated immune checkpoint inhibitor-related encephalitis (ICI-encephalitis) to better understand its characteristics, identify diagnostic biomarkers, and explore factors predicting patient outcomes.* -
- It analyzed data from 67 patients (median age 69 years) diagnosed between 2015-2023, finding that 64% had focal syndromes (like limbic encephalitis) while 36% had meningoencephalitis, with the former showing worse treatment responses and higher mortality rates.* -
- The presence of PNS-related antibodies and abnormal MRI findings were more common in focal encephalitis cases, highlighting important distinctions that could guide future diagnostics and therapeutic strategies.*
REM and NREM Sleep Parasomnia in Anti-NMDA Receptor Encephalitis.
Neurol Neuroimmunol Neuroinflamm
September 2024
Objectives: Encephalitis with anti-N-methyl-d-aspartate receptor antibodies (anti-NMDARe) is a rare disorder characterized by cognitive impairment, psychosis, seizures, and abnormal movements. Abnormal behaviors during REM sleep have not been described in anti-NMDARe.
Methods: Patients were monitored by video-polysomnography on a first night followed by multiple sleep latency tests and 18 hours of bed rest.
Background And Objectives: While patients with paraneoplastic autoimmune encephalitis (AE) with gamma-aminobutyric-acid B receptor antibodies (GABAR-AE) have poor functional outcomes and high mortality, the prognosis of nonparaneoplastic cases has not been well studied.
Methods: Patients with GABAR-AE from the French and the Dutch Paraneoplastic Neurologic Syndromes Reference Centers databases were retrospectively included and their data collected; the neurologic outcomes of paraneoplastic and nonparaneoplastic cases were compared. Immunoglobulin G (IgG) isotyping and human leukocyte antigen (HLA) genotyping were performed in patients with available samples.