Publications by authors named "D Prvulovic"
Background: Coronary bifurcation lesions are associated with less favourable outcome as compared to other lesion subsets. The role of drug-coated balloons (DCB) for bifurcation lesions has been only investigated in small studies so far, which reported encouraging results. We here describe the results of EASTBOURNE-BIF prospective registry, in which a sirolimus-DCB was used for the treatment of bifurcation lesions.
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- The study aims to investigate how a supportive decision-making approach focusing on relational aspects can help individuals with dementia in Alzheimer's disease (PwAD) make self-determined decisions in a familiar home environment rather than a clinical one.
- Researchers will recruit 80 participants from memory clinics and use a randomized crossover design to assess if the location of decision-making affects their overall capacity to consent.
- The findings could lead to the development of new strategies for supported decision-making that leverage relational resources, prompting future research to explore effective interventions further.
Project DECIDE, part 1: increasing the amount of valid advance directives in people with Alzheimer's disease by offering advance care planning-a prospective double-arm intervention study.
BMC Med Ethics
December 2022
Background: Everybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer's dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists.
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- * A study in Germany tested whether adding minocycline (200 mg/day) to standard antidepressant treatment over 6 weeks could significantly reduce depressive symptoms in TRD patients.
- * The trial involved 258 screened patients with 168 included and randomized into either the minocycline or placebo group, tracking outcomes to assess the effectiveness of the intervention.
Background: Alzheimer's disease (AD) pathology is present many years before the onset of clinical symptoms. AD dementia cannot be treated. Timely and early detection of people at risk of developing AD is key for primary and secondary prevention.
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