[Identity, destiny and schizophrenia].

In his work « Phenomenology of Psychosis » Arthur Tatossian tends to report the basal alteration of patients to a constrained phenomenological reduction and deducts the drive of daily life as a sensitive point of the schizophrenic experience, vulnerability and mark of his destiny. This perspective reveals the challenge of the dynamics of human identity. Going beyond the spatial figure of a split, Alfred Kraus takes up the living format of the dynamics of « role », which regulates the relation of the subject to Self and others, and suggests to report symptoms and syndromes, another stake destined, to one of the variants dialectics of the balance between self and others.

[How to assess curative and/or preventive effects of psychotropic drugs?].

Proving the efficacy of a psychotropic drug is a medical, scientific and ethical need. Psychotropic drug development is now a highly complex process, which takes several years and which is very expensive. It involves multiple steps of preclinical and clinical pharmacological refinement and testing.

[How may practitioners interpret the results of clinical trials?].

To correctly interpret the results of a randomised controlled trial (RCT), practitioners have to spot bias and other potential problems present in the trial. Internal as well as external validity of the trial are linked to the presence of such bias. The internal validity is ensured by a clear definition of the objectives of the trial.

[Inclusion criteria and rating scales for RCTs in Psychiatry. The future of qualitative studies].

An inventory on the two critical dimensions that structure the Randomized Controlled Trial in Psychiatry, namely the definition of inclusion criteria for eligible patients for testing and the choice of psychometric methods of pathology assessment and its evolution during the experiment, considers the importance of increasingly numerous and precise international recommendations. Taking into account the formal constraints of industrial, questioning the cultural differences of the methodological approach of the tests, meeting the requirements of feasibility and ever increasing security, frequent cumbersome procedure often contrasts with the modest nature of the results. A better definition to include patients in randomized trials is desirable and it asks to return to the clinic studying the expectations of patients and their response to the therapeutic situation.

[Psychopathological aspects of negative symptoms in schizophrenia].

During the past ten years, research on schizophrenia has witnessed a clear emphasis on studies based on negative symptoms. This interest can be explained in terms of diagnosis, specific treatment, functional prognosis and outcome issues. However, main current approaches consider negative symptoms from an operationalist view, which implies objective and atheoretical descriptions of clinical criteria, observed from a third person perspective.