A sex-specific homologue of waprin is essential for embryonic development in the red flour beetle, Tribolium castaneum.

Waprin, a WAP (Whey acidic protein) domain-containing extracellular secretory protein, is widely known for its antibacterial properties. In this study, a waprin homologue (Tc_wap) expressing in a female-specific manner was identified in Tribolium castaneum, through the analysis of sex-specific transcriptomes. Developmental- and tissue-specific profiling revealed the widespread expression of Tc_wap in adult female tissues, particularly in the ovary, gut and fatbody.

Water-assisted cascade synthesis of trifluoromethylated dipyridodiazepinone analogues: and antibacterial studies.

A base-promoted palladium-catalyzed cascade reaction is described to access trifluoromethylated dipyridodiazepinone derivatives in an aqueous system (1,4-dioxane-HO). This methodology uses simple chemicals, has a broad substrate scope, is waste minimized (-factor = 0.3-0.

Green advancements towards the electrochemical synthesis of heterocycles.

Heterocyclic chemistry is a large field with diverse applications in the areas of biological research and pharmaceutical advancement. Numerous initiatives have been proposed to further enhance the reaction conditions to reach these compounds without using harmful compounds. This paper focuses on the recent advances in the eco-friendly and green synthetic procedures to synthesize N-, S-, and O-heterocycles.

1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile.

Triazine is an important pharmacophore in the field of research for the development of novel medications due to its presence in numerous powerful physiologically active compounds with significant medical potential, such as anti-tumor, anti-viral, anti-inflammatory, anti-microbial, anti- HIV, anti-leishmanial and others. The easy availability of triazine, high reactivity, simple synthesis of their analog, and their notable broad range of biological activities have garnered chemist interest in designing s-triazine-based drugs. The interest of medicinal chemists has been sparked by the structure-activity relationship of these biologically active entities, leading to the discovery of several promising lead molecules.

Synthetic and pharmacological developments in the hybrid s-triazine moiety: A review.

This article summarizes the most recent advancements in the synthetic and pharmacological approaches along with the structure activity relationship towards the s-triazine and its derivatives. Much attention has been given to s-triazine core due to its facile synthesis, interesting pharmacology, high reactivity, and binding characteristics towards various enzymes. An array of biological applications has been demonstrated by s-triazines including antimalarial, anti-HIV, anti-viral, antimicrobial, anti-tuberculosis to name a few.