Publications by authors named "D Pozzi"
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, the ability of LNPs to effectively encapsulate large-size DNA molecules remains elusive. This is a significant limitation, as the successful delivery of large-size DNA holds immense potential for gene therapy.
View Article and Find Full Text PDFPolyethylene glycol (PEG) is a common surface modification for lipid nanoparticles (LNPs) to improve their stability and in vivo circulation time. However, the impact of PEGylation on LNP cellular uptake remains poorly understood. To tackle this issue, we systematically compared plain and PEGylated LNPs by combining dynamic light scattering, electrophoretic light scattering, and synchrotron small-angle X-ray scattering (SAXS) that unveils a striking similarity in size and core structure but a significant reduction in surface charge.
View Article and Find Full Text PDFArticle Synopsis
- - The study introduces the PRIMA-17 model, which focuses on how prenatal exposure to interleukin 17A (IL-17A) from the mother affects the behavior of mouse offspring.
- - This model uniquely examines the effects of IL-17A through embryo-specific responses, allowing researchers to understand its specific role in causing behavioral disturbances.
- - The findings highlight that exposure to IL-17A during development leads to communication issues and increased anxiety-like behaviors in adult mice, emphasizing the model's utility for studying neurological deficits.
Article Synopsis
- CD8 T cells are crucial for controlling tumors but often become dysfunctional in the tumor environment; sodium chloride (NaCl) has been found to counteract this dysfunction and promote cancer regression.
- Supplementing NaCl during CD8 T cell culture enhances their activation and effectiveness while preserving key gene networks associated with T cell plasticity, leading to improved anti-tumor responses in mouse models.
- The research suggests that NaCl affects CD8 T cell function by boosting their glutamine consumption, which is essential for their overall effectiveness, indicating potential new strategies for enhancing cancer immunotherapy in humans.