Nasal immunotherapy at constant dosage: a double-blind, placebo-controlled study in grass-allergic rhinoconjunctivitis.

A preliminary open study showed that intranasal immunotherapy can be administered with a constant dosage scheduling, with good safety and efficacy. In the present study the efficacy of constant dosage intranasal immunotherapy has been evaluated on 43 grass-allergic rhinitis patients according to a double-blind placebo-controlled design. The product employed for the study had a formulation in powder, and was administrated by a nasal insufflator.

Two cases of toxic epidermal necrolysis caused by delayed hypersensitivity to beta-lactam antibiotics.

The authors describe two cases of toxic epidermal necrolysis (TEN) caused by delayed hypersensitivity to semisynthetic penicillins. The first patient developed erythema of the lower limbs following an i.m.

[Allergy to beta-lactam antibiotics in childhood. Diagnostic problems].

This study reports about 126 children with an age ranging from 12 months to 12 years having RA to beta-lactamase. More children with an age ranging from 7-12 years (59.5%), and more male (65.