Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU.

Background: Remdesivir is a prodrug with in vitro activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Its clinical efficacy in patients with COVID-19 under mechanical ventilation remains to be evaluated.

Methods: This study includes patients under mechanical ventilation with confirmed SARS-CoV-2 infection admitted to the ICU of Pesaro hospital between 29 February and 20 March 2020.

[Preliminary verification of a mathematical model for evaluating the operative risk in a personal caseload].

The authors applied a mathematical model of evaluation of operative risk to a group of patients undergoing general and obstetric-gynecologic surgery. They verified that all risk factors identified by this mathematical model really influenced operative morbidity and mortality in the present study too. In this univariate analysis, anesthetic technique was found to influence patients' outcome, so it must be included in multivariate analysis protocols.