[Laboratory animals in toxicological studies].

Basing on up-to-date knowledge on laboratory animals, a controversial problem of selection of inbred (homozygous) or outbred (heterozygous) animals for toxicological experiments has been presented. Source information on the requirements--mandatory in the world--related to animal breeding for toxicological experiments and description of animal material in publications have been included.

Subcellular distribution of inflammatory mediators in guinea-pig polymorphonuclear granulocytes (PMNL).

The experiments were performed for localizing the inflammation-inducing factors in the subcellular fractions of human and guinea pig PMNL. The magnitude of the induced inflammation tested on rats and guinea-pigs represented combined effects of all proteins extracted from PMNL. The isolation of PMNL subcellular components did not elevate the potency of the inflammatory response.

The effects of LSD and propranolol on the motor activity in rabbits.

In the investigations on the effects of LSD and propranolol on the rabbit motor activity an original device counting and recording all movements of the animals was used. LSD, administered to rabbits in a dose of 0.1 mg/kg i.