Publications by authors named "D Perra"
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially life-threatening disorder. Treatment advances have lowered morbidity rates, but past acute events can still cause long-term consequences, reducing health-related quality of life (HRQoL) and determining cognitive impairment, anxiety, and depression. We aimed to investigate these aspects and the role of caplacizumab and rituximab: 39 patients were evaluated using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), the FACIT-Fatigue, the Hospital Anxiety and Depression Scale, and the Functional Assessment in Cancer Therapy-Cognitive Function questionnaires.
View Article and Find Full Text PDFBackground: In patients with Parkinson's disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies. It is unknown whether these variable results might be related to a different distribution of pathological α-syn in OM. Thus, we investigated whether nasal swab (NS) performed in areas with a different coverage by olfactory neuroepithelium, such as agger nasi (AN) and middle turbinate (MT), might affect the detection of pathological α-syn.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of cerebrospinal fluid real-time quaking-induced conversion (CSF RT-QuIC) in diagnosing sporadic Creutzfeldt-Jakob disease (sCJD) across different European laboratories.
- A ring-trial involving 13 labs from 11 countries tested 10 identical CSF samples, revealing that most labs correctly identified sCJD cases, although some differences occurred.
- The findings highlight that CSF RT-QuIC shows strong agreement in results despite varied testing methods, suggesting its broader adoption in CJD diagnosis is beneficial.