Publications by authors named "D Peiteado"
Background: One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specificities and positive predictive values. Hyperuricemia and gout are common in chronic kidney disease (CKD), especially with glomerular filtration rate (GFR) <60, and both are associated with worse prognosis, although treatment of AH in CKD is not yet recommended in all guidelines.
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- A distinct type of regulatory T cells, known as cTreg39+, play a role in reducing inflammation by converting pro-inflammatory adenine nucleotides into adenosine and their interaction with methotrexate (MTX) was studied in early rheumatoid arthritis (eRA).
- In a study involving 98 untreated eRA patients and 98 healthy controls, it was found that higher levels of cTreg39+ cells at baseline were associated with achieving low disease activity after 12 months of MTX treatment.
- The results indicate that MTX enhances the effectiveness of cTreg39+ cells while their baseline frequency can predict how well a patient will respond to MTX, suggesting that monitoring these cells could guide prompt treatment
Subsequent biologic and targeted synthetic disease modifying anti rheumatic drugs after fulfilling difficult-to-treat rheumatoid arthritis criteria: a survival analysis.
Clin Rheumatol
September 2024
Article Synopsis
- The study evaluates the effectiveness and survival rates of various biologic and targeted-synthetic drugs for patients with difficult-to-treat rheumatoid arthritis (D2TRA).
- Out of 122 patients analyzed, 61.5% continued treatment with better survival linked to drugs like rituximab, while others like abatacept showed poorer survival rates.
- Key factors influencing treatment discontinuation included the choice of the drug and higher Disease Activity Score (DAS28) six months post-treatment initiation.
Introduction: The nature of the relationship between inflammation, cardiovascular (CV) risk factors and atherosclerosis in axial spondyloarthritis (axSpA) remains largely unknown and sex differences in this regard are yet to be assessed.
Methods: Study including 611 men and 302 women from the Spanish multicentre AtheSpAin cohort to assess CV disease in axSpA. Data on CV disease risk factors were collected both at disease diagnosis and at enrolment, and data on disease activity, functional indices and carotid ultrasonography only at enrolment.
Article Synopsis
- * A retrospective analysis of EHR data from 4337 patients diagnosed with SpA revealed that the majority were men, with a mean age of 50.9, and identified various subtypes and common comorbidities such as hypertension and diabetes.
- * The NLP system proved effective in accurately detecting clinical information, achieving high precision and recall metrics, underscoring its usefulness in characterizing the SpA patient population and supporting