Publications by authors named "D Pati"
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs are expressed in numerous brain regions associated with the regulation of appetitive behaviors.
View Article and Find Full Text PDFIn a traditional Gaussian graphical model, data homogeneity is routinely assumed with no extra variables affecting the conditional independence. In modern genomic datasets, there is an abundance of auxiliary information, which often gets under-utilized in determining the joint dependency structure. In this article, we consider a Bayesian approach to model undirected graphs underlying heterogeneous multivariate observations with additional assistance from covariates.
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- - Nonhost resistance (NHR) is a key form of innate immunity in plants, notably contributing to defense against rice blast disease caused by the fungus Magnaporthe oryzae, with specific genes like Arabidopsis PEN2 playing crucial roles in resistance.
- - Researchers discovered that the gene MTHFR2 is essential for enhancing resistance to M. oryzae independently of PEN2, with MTHFR2-defective plants showing increased defense responses and altered metabolic profiles that affect the growth of the fungus.
- - This study highlights MTHFR2 as a significant facilitator of NHR, indicating that folate-mediated 1C metabolism plays a critical role in plant defenses, providing insights that could enhance crop improvement
Purpose: The purpose of this study was to analyse the independent prognostic significance of perineural invasion (PNI) on local recurrence (LR) in patients with oral squamous cell carcinoma (OSCC) managed primarily with surgery.
Subjects And Methods: Clinical and histopathological data of 195 patients with OSCC were analysed retrospectively to identify risk factors associated with PNI and to evaluate its significant correlation with local recurrence, overall survival (OS) and recurrence free survival (RFS).
Results: Patients were followed for a mean period of 39.
We commonly encounter the problem of identifying an optimally weight-adjusted version of the empirical distribution of observed data, adhering to predefined constraints on the weights. Such constraints often manifest as restrictions on the moments, tail behavior, shapes, number of modes, etc., of the resulting weight-adjusted empirical distribution.
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