Absence of nocturnal acid breakthrough in Helicobacter pylori-positive subjects treated with twice-daily omeprazole.

Background: Proton pump inhibitors (PPIs) taken twice daily do not effectively control night-time intragastric pH; nocturnal acid breakthrough (NAB) (arbitrarily defined as intragastric pH < 4 lasting longer than 1 h) occurs in more than 75% of patients. The effectiveness of PPIs depends rather on the Helicobacter pylori status.

Objectives: To investigate the effectiveness of two regimens of omeprazole in H.

Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis.

Background: Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori. Fermented milk containing Lj1 (LC1), coadministered with antibiotics had a favourable effect on H. pylori gastritis.

Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors.

Background: Rapid and consistent acid suppression on the first day of dosing may be important in treating acid-related disorders.

Aim: To compare the antisecretory activity and onset of action of single doses of rabeprazole, lansoprazole, pantoprazole, omeprazole capsule, omeprazole multiple unit pellet system (MUPS) tablet and placebo in healthy Helicobacter pylori-negative subjects.

Methods: This cross-over, double-blind, randomized study was performed in 18 H.

13C urea breath test (UBT) in the diagnosis of Helicobacter pylori: why does it work better with acid test meals?

Background: Acid test meals may improve the accuracy of the (13)C urea breath test (UBT). This has been attributed to changes in gastric emptying rather than to the effects of gastric pH on Helicobacter pylori urease.

Aims: To determine whether enhancement of (13)CO(2) excretion in the UBT in H pylori infected volunteers by acidification of a test meal is due to a delay in gastric emptying.

Helicobacter pylori infection in Swiss adolescents: prevalence and risk factors.

Objective: This investigation sought to study the influence exerted by demographic and socioeconomic factors on the prevalence of infection in adolescents living in Switzerland.

Design: Epidemiological study spanning 3 years.

Methods: We included 196 15- to 16-year-old adolescents from a north-eastern Swiss city in our study, recruited by the school health service during a medical check-up in the years 1999, 2000 and 2001.