Publications by authors named "D Panayotova-Dimitrova"
Article Synopsis
- The study focuses on the NLRP1 inflammasome, which is crucial for skin immune response, and aims to evaluate its activation in different keratinocyte cell lines.
- Researchers compared NLRP1 activation, expression, and cell death in primary keratinocytes and immortalized cell lines (HaCaT, HaSKpw, SVTERT) after UVB irradiation or treatment with talabostat.
- Findings indicated that primary keratinocytes showed the highest NLRP1 expression and detectable inflammasome activation, suggesting that they are the preferred model for studying inflammasome activation over immortalized keratinocyte cell lines.
Introduction: Current cancer research has led to a renewed interest in exploring lysosomal membrane permeabilization and lysosomal cell death as a targeted therapeutic approach for cancer treatment. Evidence suggests that differences in lysosomal biogenesis between cancer and normal cells might open a therapeutic window. Lysosomal membrane stability may be affected by the so-called ' characterized by higher lysosomal abundance and activity and more intensive fusion or interaction with other vacuole compartments.
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- The microenvironment in aggressive tumors like glioblastoma is often acidic and deprives nutrients, impacting cancer cell behavior.
- ASICs (acid-sensing ion channels) are known to respond to pH changes, and while certain ASICs were found in glioblastoma stem cells, they did not influence their migration in acidic conditions.
- The study discovered that while ASIC-related channels didn't affect migration, the phosphoinositide 3-kinase (PI3K) pathway did play a crucial role in promoting migration of these cells in low pH environments.
Pemphigus vulgaris (PV) is a chronic, life-altering autoimmune disease due to the production of anti-desmoglein antibodies causing the loss of cell-cell adhesion in keratinocytes (acantholysis) and blister formation in both skin and mucous membranes. The dispase-based keratinocyte dissociation assay (DDA) is the method of choice to examine the pathogenic effect of antibodies and additional co-stimuli on cell adhesion in vitro. Despite its widespread use, there is a high variability of experimental conditions, leading to inconsistent results.
View Article and Find Full Text PDFTNF is a proinflammatory cytokine that is critical for the coordination of tissue homeostasis. RIPK1 and TRADD are the main participants in the transduction of TNF signaling. However, data on the cell fate-controlling functions of both molecules are quite controversial.
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