Publications by authors named "D Pallotta"
Article Synopsis
- The study examines how total IgA levels affect the accuracy of non-invasive celiac disease (CeD) diagnoses using tTG-IgA thresholds.
- Results show that varying tTG-IgA cutoffs can significantly impact specificity and sensitivity, especially depending on the total IgA levels of patients.
- The findings suggest that clinicians should consider total IgA levels alongside traditional measures for more accurate CeD diagnoses.
Background: Most patients receiving atezolizumab-bevacizumab (AB) for hepatocellular carcinoma will eventually experience disease progression. Randomized clinical trials (RCTs) are undergoing to identify second-line treatments. Where RCTs are unavailable or patients are non-eligible, sorafenib is often prescribed based on approval and reimbursement policies.
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- The review discusses the development of cancer staging for intermediate hepatocellular carcinoma (HCC), highlighting the challenges faced by doctors with the current systems, particularly the BCLC staging introduced in 1999.
- Criticism has arisen regarding the BCLC-B stage’s diverse patient population, prompting the creation of alternative subclassification systems like the Bolondi and Kinki criteria, which aim to better predict patient outcomes.
- The text advocates for a shift towards personalized treatment approaches that prioritize effective treatment options rather than just cancer stages, emphasizing the importance of a multidisciplinary approach in HCC management.
Celiac disease (CD) is frequently associated with other autoimmune disorders. Different studies have explored the association between CD and single autoimmune endocrine disease (AED), especially autoimmune thyroiditis (AIT) and type-1 diabetes mellitus (T1DM). Data about CD as a component of autoimmune polyendocrine syndrome (APS) are scant.
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- Metabolic bone disease is common among patients with coeliac disease (CD), but management guidelines vary due to insufficient long-term data.
- A 10-year study on 107 CD patients showed that bone density was stable over time, with minor fluctuations and no significant overall changes in fracture risk.
- The findings suggest that patients with osteopenia and no risk factors might benefit from less frequent monitoring, while those with osteoporosis should continue standard follow-up practices.