Ochronotic Arthropathy and Alkaptonuria (Ochronosis): Case Report.

Alkaptonuria (AKU) is a rare genetic condition resulting from a deficiency in the homogentisic acid oxidase enzyme, which is produced by the liver and kidneys, that interferes with the metabolism of the amino acids phenylalanine and tyrosine. Although it may not cause symptoms, AKU can lead to ochronosis, the abnormal accumulation in body tissues of a pigment called alkapton. Over time, this pigment accumulation in the joints may result in secondary osteoarthritis known as ochronotic arthropathy, the most debilitating form of the disease.

Benzocarbazoledinones as SARS-CoV-2 Replication Inhibitors: Synthesis, Cell-Based Studies, Enzyme Inhibition, Molecular Modeling, and Pharmacokinetics Insights.

Endemic and pandemic viruses represent significant public health challenges, leading to substantial morbidity and mortality over time. The COVID-19 pandemic has underscored the urgent need for the development and discovery of new, potent antiviral agents. In this study, we present the synthesis and anti-SARS-CoV-2 activity of a series of benzocarbazoledinones, assessed using cell-based screening assays.

Association between low back pain perception and occupational in hospital nursing professionals.

Introduction: Low back pain can be defined as pain and/or discomfort between the coastal margins of the lowest rib and the gluteal fold, and it can cause motor dysfunction, loss of productivity, and changes in job function. There is a greater number of nursing professionals in hospital environments, and, regardless of their numerical contingent, they have the highest percentage of absenteeism due to this condition.

Objectives: To evaluate the association between perception of low back pain and occupational stress in hospital nursing professionals.

Economic Evaluation of Conservation through Use of an Provenance and Progeny Test.

is a species known for its valuable wood and nuts, but it is threatened with extinction. The plantation of forests for genetic resource conservation is a complementary strategy designed to reduce the species' genetic variability loss. This study aimed to evaluate the technical and economic viability of for genetic conservation through use.