Publications by authors named "D Paine"
Article Synopsis
- Tick-borne flaviviruses (TBFV) can lead to severe brain diseases, with high rates of long-term neurological issues among survivors.
- Different mechanisms may allow flaviviruses to invade the central nervous system, and the specific method can vary based on the virus, infection site, and host.
- Research using BALB/cJ mice showed that Powassan virus lineages I and II cause differing effects on the CNS and activate distinct immune responses, correlating with unique clinical symptoms.
Disparities in Time to Diagnosis Among Patients With Multiple Myeloma.
Clin Lymphoma Myeloma Leuk
November 2023
Background: Multiple myeloma (MM) is one of the most diagnosed hematologic malignancies in the United States. Despite improvements in therapy, health disparities persist among patients with MM. Here, we aim to determine whether there are disparities in time to diagnosis (TTD) among MM patients with regard to income, race/ethnicity, and gender.
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- Constitutional mismatch repair deficiency (CMMRD) is a syndrome that increases the risk of high-grade gliomas in children, leading to poor outcomes and making treatment challenging.* -
- This study evaluates the effectiveness of the histone deacetylase inhibitor, quisinostat, on a hypermutant pediatric high-grade glioma model, showing it causes significant tumor regression and alters gene expression.* -
- The findings suggest quisinostat’s potential as a treatment option for hypermutant DIPG and indicate that loss of mismatch repair function may enhance sensitivity to this drug, encouraging further research on HDAC inhibitors for similar cancers.*
Helicopter-based shooting is an effective management tool for large vertebrate pest animals. However, animals in low-density populations and/or dense habitat can be difficult to locate visually. Thermal-imaging technology can increase detections in these conditions.
View Article and Find Full Text PDFThe cellular protein SAMHD1 is important for DNA repair, suppressing LINE elements, controlling deoxynucleoside triphosphate (dNTP) concentrations, maintaining HIV-1 latency, and preventing excessive type I interferon responses. SAMHD1 is also a potent inhibitor of HIV-1 and other significant viral pathogens. Infection restriction is due in part to the deoxynucleoside triphosphatase (dNTPase) activity of SAMHD1 but is also mediated through a dNTPase-independent mechanism that has been described but not explored.
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