[The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea].

The study was concerned with the inhibitory effect of officinal preparations of phytoadaptogenic drugs such as bioginseng and Eleutherococcus senticosus and Rhaponticum carthamoides root extracts on the carcinogenesis induced by transplacental administration of N-nitrosoethylurea. The phytodrugs were given orally over a year. The administration of the drugs was followed by longer survival of the rats and lower occurrence and/or multiplicity of tumors (mainly those of the central nervous system).

[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].

Anticarcinogenic effects of the fumaric acid was studied in two rat models of carcinogenesis. Tumors of the esophagus, forestomach, tongue and throat were induced by peroral instillation of 35 mg/kg body weight N-methyl-N-benzylnitrosamine, and neurogenic and renal ones--by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. The fumaric acid given in drinking water in the dose of 1 g/l at the postinitiation stage of the carcinogenesis was shown to inhibit the development of esophageal papilloma, brain glioma and mesenchymal tumors of the kidney.

[The inhibiting effect of epsilon-aminocaproic acid on the incidence of induced tumors of the esophagus, nervous system and kidneys].

The anticarcinogenic properties of epsilon-aminocaproic acid were studied in two rat models of carcinogenesis. Esophageal tumors were induced by oral instillations of a total dose of 54 mg/kg body weight N-methyl-N-benzylnitrosamine whereas tumors of the nervous system and kidney-by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. epsilon-Aminocaproic acid given at a concentration of 1 milligram drinking water at the post-initiation stage of the carcinogenesis was shown to inhibit the induction of cancer and papilloma of the esophagus, brain glioma, peripheral nerve neurinoma and mesenchymal tumors of the kidney.

[The inhibiting effect of ortofen and dexamethasone on the development of tumors of the cervix uteri and vagina].

The effects of nonsteroidal and steroidal drugs ortophen and dexamethasone on carcinogenesis of the uterine cervix and vagina were studied on mice. Intravaginal applications of a 0.1% solution of 7,12-dimethylbenz(a)anthracene, 2 times a week for 8 weeks, induced cervical and vaginal carcinomas in 67% of cases in 35 weeks.

[The effect of riboflavin, molybdenum, selenium and zinc on the development of induced tumors of the esophagus and forestomach in rats].

The study was concerned with the influence of prolonged treatment with riboflavin, molybdenum, selenium and zinc on the induction of tumors of the esophagus and forestomach by N-nitrososarcosine ethyl ester (NSEE) in rats. Riboflavin was fed whereas molybdenum, selenium or zinc were given in drinking water after the discontinuation of treatment with NSEE, once hyperplasia and dysplasia became evident in the mucous membrane of the esophagus and forestomach. Riboflavin and molybdenum decreased the incidence of carcinoma and multiplicity of papilloma of the organs.