Publications by authors named "D P McDonnell"
Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear. In this study, we assessed the functional effects of known RARα mutations on retinoic acid signaling using biochemical and cellular assays. All tested mutants exhibited reduced transcriptional activity compared to wild-type RARα and showed a dominant negative effect, a feature associated with developmental defects and tumor formation.
View Article and Find Full Text PDFEndocrine therapies targeting the estrogen receptor (ER/ESR1) are the cornerstone to treat ER-positive breast cancers patients, but resistance often limits their effectiveness. Notable progress has been made although the fragmented way data is reported has reduced their potential impact. Here, we introduce EstroGene2.
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- - The study evaluated the long-term safety, tolerability, and effect of olanzapine/samidorphan (OLZ/SAM) in patients with schizophrenia, schizophreniform disorder, or bipolar I disorder for up to 4 years, following the ENLIGHTEN clinical program.
- - Out of 524 enrolled patients, the majority had schizophrenia, and common adverse effects included weight gain, headache, and anxiety, with minimal changes in metabolic parameters over the treatment duration.
- - The treatment showed stable scores on the Clinical Global Impressions-Severity scale, indicating maintained symptom control and a long-term safety profile consistent with previous studies.
Post-COVID Mental Health Crises: Globally Minded for Solutions and Solidarity.
Disaster Med Public Health Prep
December 2024
Article Synopsis
- Mental health has worsened significantly around the world since COVID-19, with anxiety and depression rates increasing by 25% during the first year of the pandemic, adding to the existing burden of over 1 billion people with mental disorders.
- The shortage of mental health providers and disrupted services during the pandemic highlight the need for innovative solutions, particularly through technology, to tackle these rising mental health crises.
- However, challenges like inconsistent patient protection measures hinder the effectiveness of technological approaches, prompting a discussion on how the global community can better address mental health issues going forward.
Worldwide, women face a disproportionately heavy health burden than their male counterparts. Yet there is a chronic lack of research attention and investment in women's health, which may explain the absence of women-inclusive, let alone women-centred, understanding of the causes, consequences, and confounding factors that shape individuals' health and quality of life. In this manuscript, by analysing the U.
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