Considerations and recommendations for collaborative research networks in epidemiology: Lessons learned from the diabetes LEAD Network.

Multi-site and multi-organizational teams are increasingly common in epidemiologic research; however, there is a lack of standards or best practices for achieving success in collaborative research networks in epidemiology. We summarize our experiences and lessons learned from the Diabetes Location, Environmental Attributes, and Disparities (LEAD) Network, a collaborative agreement between the Centers for Disease Control and Prevention and research teams at Drexel University, New York University, Johns Hopkins University and Geisinger, and the University of Alabama at Birmingham. We present a roadmap for success in collaborative epidemiologic research, with recommendations focused on the following areas to maximize efficiency and success in collaborative research agreements: 1) operational and administrative considerations; 2) data access and sharing of sensitive data; 3) aligning network research aims; 4) harmonization of methods and measures; and 5) dissemination of findings.

Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease.

Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). Prior studies have implicated Hedgehog (Hh) signaling in ADPKD, with increased levels of Hh components in experimental ADPKD and reduced cystogenesis following pharmacological Hh inhibition.

Factors associated with cultural sensitivity and global nursing education among nurse educators: A cross-sectional study.

Background: Nurse educators must be culturally sensitive to teach cultural care to nursing students effectively.

Objective: To explore the factors associated with cultural sensitivity and global nursing education among nurse educators.

Methods: This was a cross-sectional exploratory study.

Coherently averaged optical frequency comb spectroscopy with a single electro-optic modulator.

We present a new, to the best of our knowledge, approach for self-heterodyne optical frequency comb (OFC) spectroscopy in which a single Mach-Zehnder modulator is utilized to generate both an optical frequency comb and a frequency-shifted local oscillator. This method allows for coherent, time-domain averaging to be performed without the need for feedback mechanisms or software corrections. As an initial demonstration, we have measured acetylene rovibrational transition frequencies with coherently averaged comb spectra.

Analysis of expression and its clinical significance of the ADAMTS-2 in systemic lupus erythematosus.

Objectives: ADAMTS-2 is a procollagen N-proteinase that plays an important role in inflammation regulation. The objective of our research is to explore the expression of ADAMTS-2 in Systemic Lupus Erythematosus (SLE), and analyze its relationship with clinical features of SLE, and evaluate the potential value of ADAMTS-2 as a diagnostic biomarker in SLE.

Methods: ADAMTS-2 expression in PBMCs was detected by RT-qPCR in SLE patients, RA patients, and healthy controls (HC).