Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy.

Currently, no approved antiviral drugs target dengue virus (DENV) infection, leaving treatment reliant on supportive care. DENV vaccine efficacy varies depending on the vaccine type, the circulating serotype, and vaccine coverage. We investigated defective interfering particles (DIPs) and lipid nanoparticles (LNPs) to deliver DI290, an anti-DENV DI RNA.

Effectiveness of the addition of visual aids to conversational preoperative education in glaucoma filtering surgery: A randomized controlled trial.

Background: This study aimed to evaluate the impact of preoperative visual aids on anxiety and pain management in patients with low educational backgrounds undergoing glaucoma filtering surgery.

Methods: A randomized, single-blinded, single-center clinical trial was conducted at a tertiary eye hospital in Shantou, China. Patients scheduled for glaucoma filtering surgery were randomly assigned to either a conventional oral education group or a visual aids group.

Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis.

Anaplastic thyroid carcinoma is one of the highly fatal cancers and poses a serious threat to human health. Ferroptosis has been widely studied and proved to have an important role in tumor suppression, providing new avenues for cancer therapy; glutathione peroxidase 4(GPX4) and selenoprotein thioredoxin reductase(TXNRD1) are important regulatory targets in ferroptosis.Warburg effect is one of the important energy sources for cancer hypermetabolism, and pyruvate kinase isoenzyme 2 (PKM2) is a key metabolism enzyme that is important in this effect.

Laser hair depilation therapy for pilonidal sinus disease: A 5-year, retrospective experience in a University Teaching Hospital in the UK, 2017-2023.

Background: Pilonidal sinus disease (PSD) is a chronic debilitating condition predominantly affecting young men. Laser hair depilation is an established adjunct to surgical treatment for PSD and can lead to reduced rates of recurrence, and post-surgical interventions.This study aimed to assess the outcome of laser hair depilation therapy on disease progression in pilonidal sinus disease patients at the Birmingham Skin Regional Laser Centre.

Photonics-assisted analog windowing and matched filtering.

In this paper, we propose an integrated method for windowing and matched filtering in the analog domain based on microwave photonic technology, which utilizes dispersion regulation of optical waveguide to achieve the windowing processing of broadband signals in the optical domain and the surface acoustic wave filter (SAWF) to achieve the following matched filtering processing in the radio frequency (RF) domain, thus realizing their integration processing in the analog domain. The proposed method is validated by simulation and experiment, in which the integrated processing of matched filtering and windowing in the analog domain for a linear frequency modulation (LFM) signal with a bandwidth of 1 GHz is carried out and the peak to sidelobe ratio (PSLR) of the output signal is -19.55 dB and the mainlobe width (MLW) broadens to 0.