Publications by authors named "D P Kiehart"

Dorsal closure is a process that occurs during embryogenesis of . During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the dorsal opening, shrinks as the lateral epidermis sheets converge and eventually merge. During this process, both shape index and aspect ratio of amnioserosa cells increase markedly.

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In bony fishes, patterning of the vertebral column, or spine, is guided by a metameric blueprint established in the notochord sheath. Notochord segmentation begins days after somitogenesis concludes and can occur in its absence. However, somite patterning defects lead to imprecise notochord segmentation, suggesting that these processes are linked.

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Dorsal closure is a process that occurs during embryogenesis of . During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the dorsal opening, shrinks as the lateral epidermis sheets converge and eventually merge. During this process, the aspect ratio of amnioserosa cells increases markedly.

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Article Synopsis
  • Dorsal closure is an embryonic process where a tissue called the amnioserosa shrinks and the lateral epidermis merges to close the dorsal opening, resulting in changes to cell shape and aspect ratio.
  • Contrary to expectations based on the standard 2D vertex model—which suggests the tissue should become fluid by changing cell neighbors—the amnioserosa behaves as a solid during this process.
  • A modified vertex model, which takes into account the gradual reduction of cell perimeter and differing cell sizes, successfully explains the amnioserosa's solid state, accurately predicts cell shape changes and junction tension, and aligns with experimental findings.
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In bony fishes, formation of the vertebral column, or spine, is guided by a metameric blueprint established in the epithelial sheath of the notochord. Generation of the notochord template begins days after somitogenesis and even occurs in the absence of somite segmentation. However, patterning defects in the somites lead to imprecise notochord segmentation, suggesting these processes are linked.

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