Publications by authors named "D P Getova"
The effects of 3,16-2-hydroxyethyl apovincaminate (HEAPO, RGH-10885) compared with those of two cholinesterase inhibitors, donepezil and galantamine, were examined in naïve Wistar rats using standard active and passive avoidance tests. The active avoidance test (shuttle box) and two passive avoidance tests (step-through and step-down) were performed according to the experimental design. There were 10 groups of rats ( = 8) and the substances studied were applied orally before each testing session.
View Article and Find Full Text PDFThe introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats.
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- Ketamine, a non-competitive blocker of NMDA receptors, has shown anti-nociceptive effects in both acute and neuropathic pain models in rats.
- The study involved treating Wistar rats with varying doses of ketamine and evaluating their pain responses through tests like the hot plate and analgesy-meter.
- Results indicated that ketamine significantly increased pain reaction thresholds and reduced discomfort in the treated groups, suggesting its potential effectiveness in managing chronic pain conditions.
Deregulated cytokines' production is found in depressed patients. Salidroside and curcumin both have been described with potential antidepressant-like activities. The present study investigated the effect of pure salidroside, curcumin and their combination on the immunoreactivity of animals, subjected to a chronic mild stress (CMS) model, followed by lipopolysaccharide (LPS)-induced inflammation.
View Article and Find Full Text PDFBackground: In blood vessels 5-HT stimulates sympathetic nerves, the endothelium and vascular smooth muscle cells. Triptans are specific anti-migraine drugs and they activate the serotoninergic 5HT1b/d receptors causing vasoconstriction of the cerebral vessels.
Aim: To evaluate the effect of frovatriptan on isolated rat carotid artery.