Papillary adenocarcinoma of the prostatic urethra with clear-cell appearance.

The second reported papillary prostatic urethral carcinoma displaying an unusual clear-cell or so-called mesonephroid histologic appearance is described. Neoplasms arising from the utricular region have generated considerable discussion of their histogenesis and hormone-responsiveness. A review of the literature as well as consideration of this case suggests that the lesion's clear-cell appearance should not be used as evidence for müllerian derivation from the utricle.

Pathological factors that influence prognosis in stage A prostatic cancer: the influence of extent versus grade.

To determine the pathologic factors useful in predicting prognosis in patients with stage A prostatic cancer we studied 117 patients followed for 2 to 15 years. Since no patient was treated until progression of disease occurred we were able to correlate pathologic findings with the natural history of the disease in an untreated population of patients. In 14 patients (12 per cent) extensive local (2) or metastatic (12) disease developed.

Comparison of spontaneous and experimentally induced canine prostatic hyperplasia.

Spontaneous prostatic hyperplasia in the beagle appears to progress with age from a glandular to a cystic histological appearance. Prostatic hyperplasia can be induced in young beagles with intact testes by treatment for 4 mo with either dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, alone, or with either of these steroids in combination with 17 beta-estradiol. In contrast, the induction of prostatic hyperplasia in young castrated beagles, in which the gland had been allowed to involute for 1 mo, requires the administration of both 17 beta-estradiol and either 5 alpha-androstane-3 alpha, 17 beta-diol or dihydrotestosterone.

Vesicoureteral reflux and ureteropelvic junction obstruction: late occurrence of ureteropelvic obstruction after successful ureteroneocystostomy.

Ureteropelvic junction obstruction occurred in 2 patients after successful correction of vesicoureteral reflux. The correction of vesicoureteral reflux does not always allow complete resolution of pelvioureteral tortuosity, kinking and periureteritis. In cases with a severe degree of these changes the possibility of ureteropelvic junction obstruction occurring either early or late after ureteroneocystostomy should be considered when unsatisfactory renal function is noted during followup.

Quantitative determination of prostatic epithelial and stromal hyperplasia by a new technique. Biomorphometrics.

Recent studies of neonatal and pathologic growth of the prostate have postulated the possible importance of stromal-epithelial interaction in the control of prostatic growth. To allow further analysis of the possible importance of this interaction, a new technique has been developed that permits quantification of the total number of stromal and epithelial cells in the prostate gland. This technique has been termed biomorphometrics and is a combination of standard morphometric and biochemical methodology.