Publications by authors named "D P D'Agostino"
Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Only limited real-life data on the long-term outcomes of CD patients treated with UST are available. This study assessed UST's long-term effectiveness and safety in a large population-based cohort of moderate to severe CD patients.
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- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Article Synopsis
- - Federated learning (FL) is a method that enhances data privacy in healthcare collaborations, with roots in both engineering and statistics, and a need for better recognition of statistical privacy-preserving algorithms.
- - The study compared seven FL frameworks from both domains, evaluating their performance using logistic regression and Lasso modeling on simulated and real-world data, revealing statistical FL algorithms yield less biased estimates while engineering methods can offer better predictions.
- - The research highlights strengths and weaknesses of both FL methods, suggesting their selection based on specific study needs, and calls for increased awareness and integration of these techniques in future healthcare applications.
This study demonstrates a simple approach to synthesize green Cu particles stabilized by poly(n-vinyl)pyrrolidone (PVP): the latter acts as stabilizer and dispersant, and its presence in solution eliminates the need for an inert atmosphere. Synthetic parameters were tuned to obtain particles with diameters >200 nm, to be human-safe and prevent nano-cytotoxicity. PVP and reductant concentrations, with reaction times, were varied to investigate their effect on colloidal stability, kinetics, and particles size.
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- Therapeutic nutritional ketosis, achieved through various dieting strategies, can help manage diseases like epilepsy, diabetes, and cancer, but sustaining it can be challenging.
- The study introduces a new synthetic triglyceride, glycerol tri-acetoacetate (Gly-3AcAc), which raises ketone levels in mice to a therapeutic range when administered.
- Results showed increased blood levels of β-hydroxybutyrate without harmful side effects, suggesting potential for this compound in enhancing methods to induce nutritional ketosis.