Publications by authors named "D P Burgner"
Aims: While COVID-19 no longer presents a global health emergency, the indirect (non-infection) impacts of the pandemic may exacerbate health inequalities in years to come. We examined the socio-economic distribution of the impacts of the pandemic on the psychosocial and economic well-being of children, young people and their families.
Methods: The CoRonavIruS Health Impact Survey (CRISIS) was conducted in seven existing longitudinal cohorts, together involving n = 3072 participants aged 0-19 years.
Introduction: Phthalates, chemical additives used to enhance plastic products' flexibility, are easily released into the environment, and can harm the brain development through various mechanisms including inflammation. Genetic variation influencing an individual's susceptibility to inflammation may play a role in the effects of phthalate exposure on neurodevelopment however there is no summary measure developed for genetic susceptibility to inflammation.
Methods: We developed a genetic pathway function score for inflammation (gPFS), based on the transcriptional activity of the inflammatory response pathway in the brain and other tissues.
Objectives: To identify evidence and guidelines relating to the use of antibiotics in the management of odontogenic facial swellings in children and adolescents.
Data: Articles relating to odontogenic facial swellings in children and adolescents aged 0-16 years were included. Articles in which paediatric data could not be differentiated from adult data or where the age of participants were unknown were excluded.
Article Synopsis
- Federated networks enhance data privacy by allowing analysis without transferring sensitive data, supporting trustworthy data analysis in healthcare research.
- The International COVID-19 Data Alliance (ICODA) tested a federated network with partners to analyze data from the International Perinatal Outcome in the Pandemic (iPOP) Study, facing both challenges and benefits in the process.
- Establishing these networks requires significant investment and planning for technology and governance, which can lead to powerful collaborative research opportunities using health data from various countries.
Article Synopsis
- The study examines the relationship between socioeconomic disadvantage and body mass index (BMI) among children and adults while considering genetic predisposition to obesity.
- By analyzing data from a sizable population-based cohort, the researchers found that children with higher polygenic risk for obesity are more affected by socioeconomic disadvantage.
- Hypothetical interventions to reduce this disadvantage could significantly lower rates of adolescent overweight/obesity, especially among those with high genetic risk, suggesting that addressing childhood disadvantage may be an effective strategy for obesity prevention.