Plastic induced urinary tract disease and dysfunction: a scoping review.

Introduction: In 2019 the World Health Organisation published a report which concluded microplastics in drinking water did not present a threat to human health. Since this time a plethora of research has emerged demonstrating the presence of plastic in various organ systems and their deleterious pathophysiological effects.

Methods: A scoping review was undertaken in line with recommendations from the Johanna Briggs Institute.

A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases.

Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging.

An Integrated Research-Clinical BSL-2 Platform for a Live SARS-CoV-2 Neutralization Assay.

A reliable and efficient serological test is crucial for monitoring neutralizing antibodies against SARS-CoV-2 and its variants of concern (VOCs). Here, we present an integrated research-clinical platform for a live SARS-CoV-2 neutralization assay, utilizing highly attenuated SARS-CoV-2 (Δ3678_WA1-spike). This strain contains mutations in viral transcription regulation sequences and deletion in the open-reading-frames 3, 6, 7, and 8, allowing for safe handling in biosafety level 2 (BSL-2) laboratories.

Mental imagery of whole-body motion along the sagittal-anteroposterior axis.

Whole-body motor imagery is conceptualised as a mental symbolisation directly and indirectly associated with neural oscillations similar to whole-body motor execution. Motor and somatosensory activity, including vestibular activity, is a typical corticocortical substrate of body motion. Yet, it is not clear how this neural substrate is organised when participants are instructed to imagine moving their body forward or backward along the sagittal-anteroposterior axis.

It's Not What You Expected! The Surprising Nature of Cleft Alternatives in French and English.

While much prior literature on the meaning of clefts-such as the English form "it is X who Z-ed"-concentrates on the nature and status of the exhaustivity inference ("nobody/nothing other than X Z"), we report on experiments examining the role of the doxastic status of alternatives on the naturalness of -clefts in French and -clefts in English. Specifically, we study the hypothesis that clefts indicate a conflict with a doxastic commitment held by some discourse participant. Results from naturalness tasks suggest that clefts are improved by a property we term "contrariness" (along the lines of Zimmermann, 2008).