Evaluating the association of genotype and cognitive resilience in SuperAgers.

Importance: "SuperAgers" are oldest-old adults (ages 80+) whose memory performance resembles that of adults in their 50s to mid-60s. Factors underlying their exemplary memory are underexplored in large, racially diverse cohorts.

Objective: To determine the frequency of genotypes in non-Hispanic Black and non-Hispanic White SuperAgers compared to middle-aged (ages 50-64), old (ages 65-79), and oldest-old (ages 80+) controls and Alzheimer's disease (AD) dementia cases.

Deep learning-based free-water correction for single-shell diffusion MRI.

Free-water elimination (FWE) modeling in diffusion magnetic resonance imaging (dMRI) is crucial for accurate estimation of diffusion properties by mitigating the partial volume effects caused by free water, particularly at the interface between white matter and cerebrospinal fluid. The presence of free water partial volume effects leads to biases in estimating diffusion properties. Additionally, the existing mathematical FWE model is a two-compartment model, which can be well posed for multi-shell data.

Does dietary supplementation of pregnant mares with a commercial stud feed balancer improve the transfer of passive immunity in their foals? A controlled field trial.

This prospective, controlled field trial aimed to determine the effect of dietary supplementation of mares in late pregnancy with a commercial stud feed balancer on the transfer of passive immunity to their foals. Eighty-two pregnant mares on a single stud farm that were eligible for inclusion were assigned into two groups (Intervention and Control) based primarily on existing social groupings. Between 64-224 days prepartum, all mares received the same forage-based diet but mares in the Intervention group received an in-feed commercial stud feed balancer and mares in the Control group received the stud's home-mix concentrate.

Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Introduction: The effects of sex and apolipoprotein E (APOE)-Alzheimer's disease (AD) risk factors-on white matter microstructure are not well characterized.

Methods: Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)-corrected and harmonized. This dataset included 4741 participants (age = 73.

Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice.

Sickle cell disease (SCD) is a severe hematological disorder characterized by erythrocyte sickling that causes significant morbidity and mortality. Skeletal complications of SCD include a high incidence of bone loss, especially in vertebrae, leading to fragility fractures that contribute to disease burden. Whether hydroxyurea (HU), a front-line therapy for SCD ameliorates bone disease has not been established.