Publications by authors named "D Ottaviani"
Article Synopsis
- Family history of Parkinson's disease (PD) was examined in a study involving 2035 PD patients across 28 Italian centers, revealing that 21.9% had a family history of the disease.
- Familial PD (fPD) patients experienced symptoms at an earlier age compared to sporadic PD (sPD) patients, although both groups showed similar prevalence of motor and nonmotor symptoms.
- The findings suggest that fPD occurs more frequently than previously thought, highlighting the need for comprehensive family history taking to uncover potential disease patterns and risk factors.
Article Synopsis
- RET is highlighted as a crucial player in breast cancer brain metastases, with overexpression linked to enhanced cancer cell adhesion and survival in the brain.
- The study utilizes various methods, including pharmacological inhibition and RNA sequencing, to explore RET's functionality and mechanisms in patient-derived tumor samples.
- Findings suggest that targeting RET could be a promising management strategy for breast cancer patients with brain metastases, particularly in those with estrogen receptor-positive tumors.
Application of the NSE score (Neurology-Stability-Epidural compression assessment) to establish the need for surgery in spinal metastases of elderly patients: a multicenter investigation.
Giuseppe Di Perna Bianca Baldassarre Daniele Armocida Raffaele De Marco Alessandro Pesaresi Davide Ottaviani
Eur Spine J
November 2024
Purpose: This retropective multicentric study aims to investigate the clinical applicability of the NSE score in the elderly, to verify the role of this tool as an easy help for decision making also for this class of patients.
Methods: All elderly patients (> 65 years) suffering from spinal metastases undergoing surgical or non-surgical treatment at the authors' Institutions between 2015 and 2022 were recruited. An agreement group (AG) and non-agreement group (NAG) were identified accordingly to the agreement between the NSE score indication and the performed treatment.