Publications by authors named "D Ostatnikova"
In this article, we present a case study of a five-year-old girl with autism and developmental delay, conducted at the Academic Center for Autism Research in Bratislava, Slovakia. The girl was diagnosed using Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and Autism Diagnostic Interview-Revised (ADI-R) instruments and met the criteria for autism spectrum disorder. Intellectual functioning was in the markedly below-average range, as indicated by the Snijders-Oomen Nonverbal Intelligence Test-Revised (SON-R) examination, and her level of adaptive functioning was significantly reduced.
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- The study investigates the impact of Shank3 deficiency on dopaminergic neurons in mouse models relevant to autism.
- Significant reductions in neurite outgrowth and altered morphology of dopaminergic neurons were observed in Shank3-deficient mice compared to wild-type (WT) mice.
- Although there were no changes in the expression of synaptic proteins, shifts in dopaminergic receptor gene expression suggest structural alterations may contribute to autistic symptoms in these models.
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by impaired social interaction and communication, restrictive and repetitive patterns of behavior, interests and activities. The aim of this study was to determine the postnatal levels of thyroid hor-mones and investigate their association with the severity of ASD symptoms. The study included 56 children (46 boys and 10 girls) with ASD aged 24-42 months.
View Article and Find Full Text PDFThe diagnostic prevalence of autism spectrum disorders (ASD) shows boys to be more affected than girls. Due to this reason, there is a lack of research including and observing ASD girls. Present study was aimed to detect hormones of steroidogenesis pathway in prepubertal girls (n = 16) diagnosed with ASD and sex and age matched neurotypical controls (CTRL, n = 16).
View Article and Find Full Text PDFObjectives: The presented research aimed to identify prenatal factors involved in abnormal neurodevelopment and postnatal manifestation of an autistic phenotype in 107 boys (average age 4.31 ± 2.24 years).
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