TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies.

Cancer is a therapeutically challenging and genomically complicated disease. Pioneering studies have uncovered multifaceted aspects of cancer, ranging from intra- and inter-tumor heterogeneity, drug resistance, and genetic/epigenetic mutations. Loss of apoptosis is another critical aspect that makes cancer cells resistant to death.

Optimization of Radiology Diagnostic Services for Patients with Stroke in Multidisciplinary Hospitals.

Background: Effective radiology diagnostic services are crucial for the timely and precise diagnosis and treatment of stroke, a medical emergency, in multidisciplinary hospitals. However, the efficiency of these services might be impeded by various logistical and operational challenges present in a multidisciplinary hospital setup.

Objective: This review endeavours to explore the ways for optimizing stroke management in multi-disciplinary hospitals, delving into its benefits, current challenges, and future prospects.

Evaluating the Effectiveness of a Modified Colorectal Cancer Screening Program in Almaty, Kazakhstan.

Objective: This study aimed to evaluate the effectiveness of a modified colorectal cancer (CRC) screening program, incorporating culturally tailored strategies to increase screening uptake and compliance, in Almaty, Kazakhstan.

Methods: A cross-sectional study was conducted in Almaty between 2019-2022, involving 5370 participants aged 50-70 from diverse settings. Participants were assigned to the main (modified method) and comparison (standard method) groups based on the parity of their ID number digits.

Prevalence of chronic kidney disease in Kazakhstan: evidence from a national cross-sectional study.

To date, there have been no large-scale national studies of the prevalence of chronic kidney disease in Kazakhstan. It includes the research based on the analysis of the estimated glomerular filtration rate (eGFR). The aim of this study was to investigate the population prevalence of CKD and associated risk factors in Kazakhstan.

Epidemiological Analysis of HIV/AIDS in Kazakhstan During 2018-2020.

Background: The human immunodeficiency virus (HIV) is a severe threat to public health everywhere, including the Central Asian region and Kazakhstan. The aim of the study was to conduct an epidemiological analysis of newly diagnosed cases of HIV infection during 2018-2020.

Study Design: A case series study.