Publications by authors named "D Orsal"
Article Synopsis
- Spinal cord lesions in humans lead to motor deficits, neurovegetative issues, and severe neuropathic pain that doesn't respond well to traditional painkillers.
- Research focused on sensory changes, drug responses, and gene expression related to injury in rats after complete spinal cord transection (SCT) at the T8-T9 level, examining effects over two months.
- Results showed significant mechanical and cold sensitivity, with gene markers for nerve injury and inflammation being strongly expressed, while certain drugs (like ketamine and morphine) were effective in reducing pain responses, contrasting with others that showed no effect.
The deletion of microtubule-associated protein stable tubule only polypeptide (STOP) leads to neuroanatomical, biochemical and severe behavioral alterations in mice, partly alleviated by antipsychotics. Therefore, STOP knockout (KO) mice have been proposed as a model of some schizophrenia-like symptoms. Preliminary data showed decreased brain serotonin (5-HT) tissue levels in STOP KO mice.
View Article and Find Full Text PDFThe present study was designed to compare the firing profiles exhibited by lumbar flexor or extensor motoneurons in response to injection of depolarizing/repolarizing currents. Motoneurons were recorded intracellularly in the in vitro brainstem-spinal cord of newborn rats (P4-P7). They were synaptically isolated and identified by antidromic stimulations of the central stump of flexor or extensor muscle nerves: tibialis anterior (ankle flexor) and gastrocnemius medialis or lateralis (ankle extensors).
View Article and Find Full Text PDFThe present study provides an account of a sensitive and rapid experimental approach for MRI visualization and analysis of spinal cord (SC) laminar activity in normal and injured animals. This approach is based upon neuronal activity-dependant manganese (Mn) uptake after focal SC injection of MnCl(2), and subsequent ex-vivo magnetic resonance imaging (MRI) of activated SC pathways. The method was designed as an alternative to time-intensive histochemical and behavioral approaches typically used for analysis of spinal cord injury (SCI) and our results provide both anatomical and functional insights.
View Article and Find Full Text PDFIn chronic spinal rats, long-term stimulation of 5-HT receptors with quipazine or 8-OHDPAT by means of daily injection, promotes robust locomotor recovery. The question of a possible potentiation between treatments when applied together was addressed. Daily injections of both 8-OHDPAT and quipazine, were performed for a month in spinal animals.
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