The effect of oral and subcutaneous meperidine on the maximal electroshock seizure (MES) in mice.

The likely effect of oral and subcutaneous meperidine on maximal electroshock seizure (MES) in mice was studied. Convulsive current fifty (CC50) was assessed to be 46m A, an electrical pulse causing seizure in 50% of test animals. Doses of 15, 30, 60, or 120 mg/kg meperidine given orally or subcutaneously increased the convulsion threshold of MES as evidenced by a significant dose-dependent reduction of MES below control value (p < .

The role of mast cells in the genesis of acute manifestations following the intravenous injection of meperidine in dogs.

The effects of intravenous (iv) administration of the synthetic opioid analgesic meperidine in conscious dogs and their relation to histamine stored in mast cells were studied in comparison with those induced by compound 48/80, potent mast cell degranulator. When 48/80 (0.5 mg/ kg) and meperidine (10 mg/kg) were injected iv into conscious dogs, an acute brief period of yelling, flare reaction, scratching, hypersalivation, urination, defecation, and tachypnea occurred after a latency of 30-35 sec.

The stability of choline ascorbate.

The stability of choline ascorbate was studied considering concentration, temperature, and pH of the drug solution. Our results revealed that choline ascorbate is almost fully stable with respect to these parameters. Practically no loss was observed when 3 x l0(-1) (50%) drug solution is preserved in the refrigerator, at ambient temperature, or at 37 degrees C for one year, a finding that favors the high stability of this compound.

The effects of compound 48/80, morphine, and mast cell depletion on electroshock seizure in mice.

Aim: The effects of compound 48/80 (C48/80), morphine, and mast cell depletion on maximal electroshock seizure (MES) were studied in Swiss albino mice.

Experimental: An electrical current (60Hz, 0.2 msec) inducing convulsions in 50% of the animals (CC50) was assessed as 46 mA.

Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms.

We studied the renovascular action of adenosine on isolated perfused rat 10 min after drug injections. Adenosine was applied intraarterially as a single bolus injection in logarithmically increasing doses (0.3-30 microg).