Publications by authors named "D O Stram"
Purpose: There are complex and paradoxical patterns in lung cancer incidence by race/ethnicity and gender; compared to non-Hispanic White (NHW) males, non-Hispanic Black (NHB) males smoke fewer cigarettes per day and less frequently but have higher lung cancer rates. Similarly, NHB females are less likely to smoke but have comparable lung cancer rates to NHW females. We use a multistage carcinogenesis model to study the impact of smoking on lung cancer incidence in NHB and NHW individuals in the Multiethnic Cohort Study (MEC).
View Article and Find Full Text PDFArticle Synopsis
- Recent studies indicate that exposure to fine particulate matter (PM) is linked to an increased risk of breast cancer, particularly among diverse populations, but data is limited.
- In a large study of 58,358 women from the Multiethnic Cohort in California, researchers found a significant association between PM and breast cancer incidence, noting variations based on family history but not on race or hormone receptor status.
- The study emphasizes the need for both personal and population-level strategies to reduce PM exposure in order to help prevent breast cancer, especially in areas where incidence rates are rising.
Association of Urinary Biomarkers of Tobacco Exposure with Lung Cancer Risk in African American and White Cigarette Smokers in the Southern Community Cohort Study.
Cancer Epidemiol Biomarkers Prev
August 2024
Background: After accounting for smoking history, lung cancer incidence is greater in African Americans than Whites. In the multiethnic cohort, total nicotine equivalents (TNE) are higher in African Americans than Whites at similar reported cigarettes per day. Greater toxicant uptake per cigarette may contribute to the greater lung cancer risk of African Americans.
View Article and Find Full Text PDFRetropubic Versus Transobturator Midurethral Slings at Time of Colpocleisis.
Urogynecology (Phila)
May 2024
Importance: This study aimed to evaluate if there is a difference between outcomes when retropubic or transobturator midurethral sling surgery is performed at the time of colpocleisis.
Objectives: The purpose of this study was to compare the surgical outcomes of the retropubic midurethral sling (RP-MUS) versus the transobturator midurethral sling (TO-MUS) in women who underwent concomitant colpocleisis, specifically 2-year MUS failure and 1-year lower urinary tract symptoms (LUTSs). A secondary aim was to identify factors associated with these surgical outcomes.
Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort.
Int J Hyg Environ Health
June 2024
Background: A growing literature has reported associations between traffic-related air pollution and breast cancer, however there are fewer investigations into specific ambient agents and any putative risk of breast cancer development, particularly studies occurring in populations residing in higher pollution areas such as Los Angeles.
Objectives: To estimate breast cancer risks related to ambient air toxics exposure at residential addresses.
Methods: We examined the relationships between ambient air toxics and breast cancer risk in the Multiethnic Cohort among 48,665 California female participants followed for cancer from 2003 through 2013.