Publications by authors named "D O Pennell"
Article Synopsis
- Intravoxel incoherent motion (IVIM) imaging traditionally has low sensitivity in measuring heart perfusion, prompting the development of a more effective stimulated-echo (STEAM) method for better assessment of cardiac microstructure and perfusion.
- The new STEAM-IVIM technique collects data at 20 different b-values and 6 diffusion directions, allowing thorough analysis of heart tissue in 20 healthy individuals.
- The results indicate high-quality imaging with promising IVIM parameters and diffusion tensor metrics, suggesting that this method can detect abnormalities in heart microstructure and perfusion without needing contrast agents.
Background: Echocardiography, cardiac magnetic resonance and cardiac fluorodeoxyglucose positron emission tomography (FDG-PET) imaging play key roles in the diagnosis and management of cardiac sarcoidosis (CS), but the relative value of each modality in predicting outcomes has yet to be determined. This study sought to determine the prognostic importance of multimodality imaging data over and above demographic characteristics and left ventricular ejection fraction (LVEF).
Methods: Consecutive patients newly diagnosed with CS were included.
Background And Aims: Microstructural disturbances underlie dysfunctional contraction and adverse left ventricular (LV) remodelling after ST-elevation myocardial infarction (STEMI). Biphasic diffusion tensor cardiovascular magnetic resonance (DT-CMR) quantifies dynamic reorientation of sheetlets (E2A) from diastole to systole during myocardial thickening, and markers of tissue integrity [mean diffusivity (MD) and fractional anisotropy (FA)]. This study investigated whether microstructural alterations identified by biphasic DT-CMR: (i) enable contrast-free detection of acute myocardial infarction (MI); (ii) associate with severity of myocardial injury and contractile dysfunction; and (iii) predict adverse LV remodelling.
View Article and Find Full Text PDFAims: In TRED-HF, 40% of patients with recovered dilated cardiomyopathy (DCM) relapsed in the short term after therapy withdrawal. This follow-up investigates the longer-term effects of therapy withdrawal.
Methods And Results: TRED-HF was a randomized trial investigating heart failure therapy withdrawal in patients with recovered DCM over 6 months.
Background: Myocardial fibrosis (MF) forms part of the arrhythmic substrate for ventricular arrhythmias (VAs).
Objectives: This study sought to determine whether total myocardial fibrosis (TF) and gray zone fibrosis (GZF), assessed using cardiovascular magnetic resonance, are better than left ventricular ejection fraction (LVEF) in predicting ventricular arrhythmias in patients with nonischemic cardiomyopathy (NICM).
Methods: Patients with NICM in a derivation cohort (n = 866) and a validation cohort (n = 848) underwent quantification of TF and GZF.