Publications by authors named "D O Ochiel"
Article Synopsis
- AI/ML techniques like reverse vaccinology and predictive models have been successfully used to create vaccine candidates for diseases such as COVID-19, HIV, and Hepatitis, making the vaccine development process faster and more efficient.
- The use of AI and ML in health interventions, including drug discovery and clinical development, is growing in Africa, especially in countries like South Africa, Kenya, and Nigeria.
- To build a sustainable AI/ML ecosystem in Africa, there is a need for more initiatives focused on improving knowledge, enhancing collaboration, establishing strong regulatory and ethical guidelines, and investing in necessary infrastructure.
Article Synopsis
- * Researchers collected blood samples from five acutely HIV-1 infected men in Nairobi, focusing on NK cell surface markers and functionality to assess changes related to infection and treatment.
- * Results showed significant impairments in NK cell function due to HIV-1, which were largely restored with immediate ART, though some alterations, like reduced Siglec7 expression, persisted even after treatment.
Objective: To assess the impact of the Caring for Providers to Improve Patient Experience (CPIPE) intervention, which sought to improve person-centered maternal care (PCMC) by addressing two key drivers: provider stress and bias.
Methods: CPIPE was successfully piloted over 6 months in two health facilities in Migori County, Kenya, in 2022. The evaluation employed a mixed-methods pretest-posttest nonequivalent control group design.
The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether-lumefantrine (AL)] using a proteomic microarray. Responses to over 200 antigens were significantly associated with ASMQ treatment outcome but not AL.
View Article and Find Full Text PDFBackground: Naturally acquired immunity (NAI), which is characterized by protection against overt clinical disease and high parasitaemia, is acquired with age and transmission intensity. The role of NAI on the efficacy of anti-malarial drugs, including artemisinin-based combinations used as the first-line treatment for uncomplicated Plasmodium falciparum, has not been fully demonstrated. This study investigated the role of NAI in response to artemisinin-based combination therapy (ACT), in symptomatic patients living in western Kenya, a high malaria transmission area.
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