Publications by authors named "D O Jordan"
The use of next-generation sequencing (NGS) and other high-throughput technologies in the clinical molecular diagnostics laboratory requires the application of bioinformatics pipelines and other computational tools to analyze, visualize, and store these clinical data. Clinical Bioinformaticians, individuals with the skills to develop, validate, and deploy these tools in a clinical setting, are needed to ensure that these molecular diagnostic technologies can be appropriately used for clinical care. Building on existing expertise in informatics, NGS, and clinical molecular diagnostics, the Association for Molecular Pathology (AMP) has generated a series to establish an initial Clinical Bioinformatician Body of Knowledge.
View Article and Find Full Text PDFUnderstanding how crop varieties acclimate to elevated temperatures is key to priming them for future climates. Here, we exposed two genotypes of Sorghum bicolor (one sensitive to heat shock (Sen) and one tolerant (Tol)) from multiple growth temperatures to a six-day heat shock (reaching 45°C), carrying out a suite of measurements before and during heat shock. Sen consistently reduced photosynthetic functioning during heat shock, while Tol increased its photosynthetic rate.
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- Mode of inheritance (MOI) is crucial for understanding pathogenic variants, yet most variants lack this information, particularly impacting recessive diseases.
- MOI-Pred and ConMOI are new tools developed to predict variant pathogenicity by incorporating MOI, with MOI-Pred focusing on both dominant and recessive variants through evolutionary and functional data.
- Both tools have shown high accuracy in benchmarks and real-world evaluations, with ConMOI outperforming individual methods, underscoring the benefits of using a consensus approach for variant predictions.
The roles and responsibilities of radiation safety officers (RSO), medical health physicists (MHP) and diagnostic medical physicists (DMP) have evolved significantly over the past 20 years. With the availability of enterprise software systems and aggregated data platforms for various radiologic healthcare systems, the roles of these professions are expanding beyond their original scopes in managing the Radioactive Materials License (RSO, MHP) and Machine Specific Physics Testing (DMP). Workers in medical radiation safety are transitioning from siloed workers working within their specific disciplines as new emerging technology and clinical care require these roles to evolve.
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