Publications by authors named "D O'Brien"
Inhibition of the mitochondrial deubiquitinating (DUB) enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson's disease and mitophagy-related disorders. We integrated structural and quantitative proteomics with biochemical assays to decipher the mode of action of covalent USP30 inhibition by a small-molecule containing a cyanopyrrolidine reactive group, . The inhibitor demonstrated high potency and selectivity for endogenous USP30 in neuroblastoma cells.
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- Neurophobia refers to the fear and anxiety that medical students and junior doctors experience regarding neurology and neurosurgery, leading to fewer students pursuing these specialties.
- A survey conducted with 264 medical students revealed that a significant number, 58% for neurology and 80% for neurosurgery, find these fields intimidating, highlighting a widespread issue across diverse medical schools globally.
- The study concludes that neurophobia is influenced by the complexities of neuroanatomy and neuropathology, and it can be exacerbated by negative clinical experiences.
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- Natural capital accounting can aid farmers in addressing supply chain impacts on biodiversity and reversing declines in farmland biodiversity.
- Current methods mainly focus on regional scales and struggle to effectively represent biodiversity, especially for fauna.
- By surveying bird populations across numerous farms, a framework for evaluating farm-scale biodiversity has been developed, linking bird species richness to specific ecosystem conditions and providing metrics for quantifying a farm’s biodiversity impact and conservation contributions.
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- High-grade follicular cell-derived non-anaplastic thyroid carcinomas are rare tumors, particularly in patients under 21, and are more commonly diagnosed in older adults.
- A study focused on 15 patients aged 9-20 revealed various classifications of thyroid carcinoma, including poorly differentiated and differentiated high-grade types, with specific genetic alterations noted, especially in the DICER1 and TP53 genes.
- Immunohistochemistry tests indicated the presence of BRAF V600E mutations and PTEN alterations, highlighting the molecular complexity of these thyroid cancers in younger populations.
Human activity influence Earth's environment, including the space environment hundreds to thousands of kilometers above the Earth. One direct evidence is that the 19.8 kHz electromagnetic signals launched by the North West Cape (NWC) transmitter station in Australia produce a wisp-like energy distribution of precipitating energetic electrons in Earth's inner radiation belt, observed by many Low Earth Orbiting satellites.
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