Permitted Sets and Convex Coding in Nonthreshold Linear Networks.

Hebbian theory proposes that ensembles of neurons form a basis for neural processing. It is possible to gain insight into the activity patterns of these neural ensembles through a binary analysis, regarding neurons as either active or inactive. The framework of permitted and forbidden sets, introduced by Hahnloser, Seung, and Slotine (2003), is a mathematical model of such a binary analysis: groups of coactive neurons can be permitted or forbidden depending on the network's structure.

Evaluating Practice Readiness of Advanced Pharmacy Practice Experience Students Using the Core Entrustable Professional Activities.

To evaluate levels of entrustability and practice readiness in advanced pharmacy practice experience (APPE) students using a pilot instrument designed to assess their competency in performing the entrustable professional activities (EPAs) expected of new pharmacy graduates. A pilot instrument was developed directly from EPAs to measure entrustability levels on a scale of one to five. Five APPE preceptors from several different practice areas participated.

Statin-Associated Bilateral Foot Myopathy.

Objective: To report a case of statin-induced bilateral foot myopathy that resulted from 2 different statins. A 44-year-old Caucasian male with a history of ventricular fibrillation cardiac arrest, hyperlipidemia, and coronary artery disease experienced bilateral foot pain, weakness, and soreness while taking atorvastatin 20 mg daily. The pain subsided within weeks of discontinuing atorvastatin but returned years later after the initiation of rosuvastatin.

The Use of Low-Dose Naltrexone for Chronic Pain.

The use of low-dose naltrexone for the treatment of chronic pain is novel because it is a nonopioid alternative. Oral naltrexone in a dosage range from 1 mg to 4.5 mg is referred to as low-dose naltrexone.

Recognition and Management of Anaphylaxis in Older Adults.

Objectives: To discuss medications that cause anaphylaxis in older adults and its treatment, with a focus on epinephrine.

Data Source: A search of PubMed using the terms "anaphylaxis," "drug-induced anaphylaxis," "epinephrine autoinjectable," "anaphylaxis diagnosis," "anaphylaxis treatment," and "epinephrine cost" was performed. English-language articles from January 2000 to August 2016 appearing in these searches were reviewed.