Publications by authors named "D Novack"
Article Synopsis
- Computational protein design is advancing, but finding high-affinity binders usually involves extensive experimental testing of site-saturated mutant libraries.
- The study employs massively parallel free energy methods, specifically an expanded ensemble approach, to improve prediction accuracy for designed binding proteins against influenza A H1 hemagglutinin.
- While Flex ddG predicts binding affinities more conservatively, the expanded ensemble approach better distinguishes stabilizing and destabilizing mutations, highlighting opportunities for improving simulation-based predictions in protein design.
Importance Over the last two years, dermatology has undergone significant reforms in the residency application process in efforts to reduce applicant stress, increase equity, and due to the COVID-19 pandemic. Objective We aimed to determine applicant and program director (PD) perspectives in implementing these changes over the last two application cycles. Design, setting, and participants Anonymous online surveys were administered by the Association of American Medical Colleges (AAMC) to PDs and applicants from the 2021-2022 dermatology residency application cycle.
View Article and Find Full Text PDFBackground: The data on patch testing (PT) to identify culprit medications in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are limited to scattered case reports and small case series, without analysis of overall trends to inform clinicians of its utility, methodology, and safety.
Objective: To conduct a systematic review of the practice of PT in SJS/TEN, quantify the positivity rate of common drug classes, and assess safety during testing.
Methods: PubMed was searched from inception to 2021.